HIGHKI GROWTH LABORATORY

하이키 성조숙증·성장 연구소

연구논문

  • 2017

    • 제목

      Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of Coicis Semen and Artemisia capillaris for Precocious Puberty: A Preliminary Experimental Study Using Female Rats
    • 출처

      국제전문학술지 EBCAM
    • 내용

      Background
      Precocious puberty is a common endocrine disease in children. Inappropriate activation of hypothalamic–pituitary–gonadal axis leads to the development of secondary sexual characteristics at an earlier age than normal children and causes short stature in adulthood.
      Objectives
      The aim of this study is to evaluate the preventive effects of a herbal formulation containing a mixture of Coicis Semen and Artemisia capillaris (hEIF extract) on precocious puberty.
      Methods
      The preventive effect of hEIF extract on precocious puberty in rats was evaluated by measuring blood component after 3 weeks of treatment via oral administration. Network pharmacological analyses were performed to predict the bioactive components of hEIF extract.
      Results
      In vivo studies showed that hEIF extract significantly reduced follicle stimulating hormone (FSH) levels. After treatment with 200mg/kg of hEIF extract, the FSH level was 5.33 ± 1.10 ng/mL, whereas the FSH level in the vehicle group was 46.73 ± 0.80 ng/mL. Moreover, the use of hEIF extract did not stimulate body growth and bone accretion in rats. The network pharmacological analysis led to the identification ofmultiple targets of hEIF extract related to lipolysis and the female sex hormone-related pathways.
      Conclusion
      hEIF extract can be used as an FSH inhibitor for the treatment of precocious puberty.

    • 제목

      특발성 성조숙증으로 진단받은 환아2례에 대한 증례보고
    • 출처

      대한한방소아과학회지
    • 내용

      Objectives
      The purpose of this study is to report the case of precocious puberty in two children treated by taking herbal medicine.
      Methods
      Two patients diagnosed with precocious puberty were prescribed Jogyeongseongjang-tang and were observed the effect of treatment on height, body weight, body composition, sex hormone test.
      Results
      During the treatment period, rapid progression of puberty was inhibited, and slow changes in sex hormones and steady growth were achieved.
      Conclusions
      This study showed the long-term effects of herbal medicine in treating precocious puberty, but further studies should be conducted for scientific validation.

    2016

    • 제목

      통계자료를 통한 국내 성조숙증 진료현황 분석
    • 출처

      대한한방소아과학회지
    • 내용

      Objectives
      The purpose of this study is to emphasize the importance of preventing precocious puberty. This study assessed current number of the patients with early puberty and their medical expenses from 2010 to 2015.
      Methods
      Using the data from Korean Statistical Information Service and Heathcare Bigdata Hub, number of patients diagnosed with precocious puberty by gender, age, and year from 2010 to 2015 were reviewed. Also, annual medical insurance expenses and the incidence of leuprorelin use were reviewed.
      Results
      Number of the patients with precocious puberty has increased from 29,251 in 2010 to 75,945 in 2015. Total medical insurance expenses have increased from 25,716,431 won in 2010 to 56,367,981 won in 2015. The use of lueprorelin also has increased annually from 11,097,590,000 won in 2010 to 21,617,585,000 won in 2015.
      Conclusions
      As a result, the patients diagnosed with precocious puberty are increasing in number, and their medical costs have been rising as well. It may be necessary to control the environmental causes of precocious puberty to reduce not only the physical and psychosocial health problems, but also the social costs.

    2014

    • 제목

      KI-180과 KI-188 칼슘조성물이 어린쥐의 성장발육에 미치는 영향
    • 출처

      한국식품과학회지
    • 내용

      calcium, chlorella extract, spirulina, colostrum powder, and other natural and functional components. We evaluated the growth-promoting effects of these formulae by analyzing the weight, femur and backbone, alkaline phosphatase,osteocalcin, testosterone, insulin-like growth factor (IGF)-1, and IGF binding protein-3 (IGFBP-3) of growing rats. Growing rats administered with KI-180 and KI-188 calcium showed the increase of body weight, body length, and femur weight and length of growing rats. In addition, administration of KI-180 and KI-188 calcium increased the alkaline phosphatase activity, the levels of osteocalcin and the growth hormones IGF-1 and IGFBP-3 of growing rats. The impact of KI-180 and KI-188 calcium on the physical development of growing rats suggests that the incorporation of these food formulae in the diets of growing children may promote the physical development.

    2003

    • 제목

      활혈성장산과 KC101이 흰쥐의 성장발육에 미치는 영향
    • 출처

      대한한의학회지
    • 내용

      Purpose
      Nowadays, there are many studies of growth retardation treatment by oriental medical therapy. This study was performed to evaluate the effect of Hwalhyulsungjang-san (Huoxuechengzhang-san) and KC101 on physical development in growth.
      Methods
      60 young (3 weeks old) male rats, whose mean weight was 46.8±0.7g, were divided into 5 groups: groups A, B, C, and D were fed an experimental diet containing respectively Hwalhyulsungjang-san 2.5%, Hwalhyulsungjang-san 7.5%, KC101 5.0%, and KC101 10.0%, and the other group were fed an AIN-diet containing neither Hwalhyulsungjang-san nor KC101 as a control. Study of each group used 2 rats and was repeated in 6 times. Body weight, daily weight gain, dietary intake, body length, femur length, backbone length and serum concentration of IGF-I and hemoglobin were measured.
      Result
      1. Body weight and daily weight gain of group D (KC101 10%) were highest; dietary intake of group D was also increased by 13% over the control group.
      2. Average body length of group D was increased to 1.69cm, which was 3.2% over the control group. Backbone length of group D was also increased 4% compared to control group.
      3. Serum concentration of IGF-I of group D increased 17% compared to control group.
      4. Serum concentration of hemoglobin of group B (Hwalhyulsungjang-san 7.5%) increased 8% compared to control group.
      Conclusion
      This study showed that Hwalhyulsungjang-san and KC101 composed of oriental medicinal stuffs have effect on physical development in growing rats. There were not any statistical meaning compared to control group, but this study suggests that intake of these compounds from a young age may lead to increase physical development in growth. (J Korean Oriental Med 2003;24(1):1-8